Guys, I took a chance and placed a 4500 in a print shop. He is enthralled with the copy/print technology. Ink yields compared to the JP3000 have been outrageous. He's averaging 11K per cartridge on long runs.
He has not complained about registration, and he is doing single color NCR.
As far as registration for 4 color work, the jury is still out. The JP4500 uses does the new press roiller design that is in the JP5500 and the JP8500.
As far as working with the Seri, they should find a way to make it work.
Art